Glycan-based prebiotic approaches to increase food safety in Australia

自第一个澳大利亚动物部门国家抗菌素耐药性计划(2018年)启动以来，已经提出了几种方法来减少农业中抗生素的使用，但没有人建议或试验抗生素的替代品。在这项提案中，我们的目标是开发一种新的基于多糖的益生菌策略，通过破坏重要的多糖-多糖相互作用来减少空肠弯曲菌在鸡和家禽中的定植。这项提议的结果是一种具有成本效益、不依赖抗生素和疫苗的动物饲料补充战略，它将降低人类食源性疾病的风险，从而促进澳大利亚的食品安全和公共健康。

Since the launch of the first Australian Animal Sector National Antimicrobial Resistance Plan (2018) several approaches have been suggested to reduce the use antibiotics in agriculture, however no alternatives to antibiotics have been suggested or trialled. In this proposal we aim to develop a novel glycan-based prebiotic strategy to reduce Campylobacter jejuni colonisation in chicken and poultry by disrupting important glycan-glycan interactions. Outcomes of this proposal is a cost-effective antibiotic- and vaccine-independent animal feed supplement strategy that will decrease the risk of human food-borne illness and therefore promoting food safety and public health in Australia.