Synthesis and Specific Properties of Novel Allosteric Host Compounds

笔者对上述项目进行了研究，得到了以下结果：(1)。研究了承载柔性腔的主体化合物金属离子的合成及其捕获。Pd （II）离子被吸附在宿主化合物的吡啶位点，而Pb （II）、Cu（II）和Zn （II）离子被吸附在-二羰基位点。宿主(6)形成cu -络合物(7)，在新形成的空腔中再次包含钾阳离子(2)。报道了金属离子的合成和输运。螺吡喃(6)、(7)和(8)选择性地通过液膜转运Cu （lI）离子。报道了Cu （II）离子在混合金属离子溶液中的选择性输运实验。提出了这种传递的机理。用碘盐对乙炔碳进行了多种直接胺化反应。利用烷基胺、二胺、羟胺、芳香胺、一酰胺和异氰酸酯与苯乙基磺酰肼反应得到相应的乙胺，收率高。合成了冠醚衍生物和微环自组装化合物。并对机理进行了探讨。合成了双氮冠醚（环径15和18）和密码化合物。用C-NMR研究了这些双氮冠醚与甲醇中二羧酸双碱金属盐的相互作用。例如，双氮冠醚（2b）在其空腔中与丙二酸二钾、2,2-二苄基丙二酸酯和对苯二甲酸酯一起包含。对其他具有双氮冠醚的二羧酸盐也进行了研究。

The author has studied by the above project, and foIIowing results were obtained.(1). Synthesis and its capturing of metal ion of host compounds bearing flexible cavity were carried out. Pd (II) ion was included at pyridine site of the host compound, but Pb (II), Cu(II) and Zn (II) ions were captured at beta-dicarbonyl site. Host (6) formed the Cu-complex (7) which is again included potassium cation in the newly formed cavity.(2). Synthesis and Metal ion transport were reported. Spiropyran (6), (7) and (8) transport Cu (lI) ion selectively through liquid membrane. Selective transport experiment of Cu (II) ion from the mixed metal ion solution also reported. Mechanism of this transport was proposed.(3). Various and direct aminations of acetylenic carbon by iodonium salt were carried out. Using alkylamines, diamines, hydroxylamines, aromatic amines, an amide and isocyanate reacted with phenylethynyliodonium tosylate to give corresponding ethynylamines in good yields. Synthesis were applied to crown-ether derivative and marcocyclic self-assembly compounds. Mechanism was also discussed.(4). Bis-azacrown ethers (ring size 15 and 18) and cryptands were synthesized. The interaction of these bis-azacrown ethers with dialkali metal salt of dicarboxylic acids in methanol were examined by C-NMR.Bis-azacrown ether (2b), for example, included with dipotassium malonate, 2,2-dibenzylmalonate and terephthalate in its cavity. The other dicarboxylate with bis-azacrown ethers were also examined.