Understanding co-activator function in transcriptional regulation

基因表达的变化支撑着所有细胞命运的决定，但对于转录因子（TF），转录的主要调控因子，如何与一些（但不是全部）转录辅因子相互作用以细微地改变基因表达，我们知之甚少。目的：利用创新的分子技术，我们将识别和表征TF和辅因子之间的共享和独特关系。意义：本研究对植物和动物中每一个由基因表达变化驱动的生物过程都具有重要意义。预期结果：本研究将增加我们在转录控制方面的生物学知识。益处：所获得的知识在基因组学方面有未来的应用，对生物技术和工业有广泛的影响。

A change in gene expression underpins all cell fate decisions yet there is scant knowledge about how transcription factors (TF), the master regulators of transcription, specifically interact with some, but not all, transcription cofactors to nuance gene expression. Aims: Using innovative molecular technologies we will identify and characterise the shared and unique relationships between TF and cofactors. Significance: This study is important to every biological process in plants and animals driven by a change in gene expression. Expected Outcomes: This study will increase our biological knowledge in transcription control. Benefit: The knowledge gained has future applications in genomics and broad implications for biotechnology and industry.