Mechanisms maintaining mitochondrial copper homeostasis.

该项目旨在确定铜在线粒体内进行交易和平衡的分子机制。该项目将采用综合的生物、生化、生物物理和结构方法来研究蛋白质，这些蛋白质是铜的必要性和毒性之间的平衡的基础，在这个细胞器中。这个项目将提供关于线粒体如何促进和实现细胞金属动态平衡的基本见解，以及这一过程中的缺陷如何导致线粒体缺陷的分子解释。主要好处包括研究培训、加强国际联系和对线粒体生物化学的基本见解。

This project aims to define the molecular mechanisms by which copper is trafficked and balanced within mitochondria. The project will employ an integrated biological, biochemical, biophysical and structural approach to examine the proteins which underpin the balance between the essentiality for copper and its toxicity, within this organelle. This project will deliver fundamental insights into how mitochondria contribute to and achieve cellular metal homeostasis, in addition to molecular explanations for how faults in this process result in mitochondrial defects. Major benefits include research training, strengthened international linkages and fundamental insights into mitochondrial biochemistry.