Detection of malignancies of head and neck cancer using PET and change induced by radiation therapy

正电子发射断层扫描(PET)示踪剂2-18F-氟-2-脱氧-D-葡萄糖(FDG)是肿瘤学中应用最广泛的示踪剂。本研究旨在评估正电子发射计算机断层扫描(PET)对头颈部恶性肿瘤的诊断价值，并与MRI、CT和组织病理学结果进行比较。17例恶性肿瘤患者接受了FDG检查。PET显示，每个经活检证实的原发病灶都是FDG摄取增加的区域。病理发现2例有转移性淋巴转移。FDG-PET在咽后间隙发现的最小转移淋巴结为4 mm。在注射FDG后10~60min，观察淋巴结对FDG的摄取，转移性淋巴结摄取逐渐增加，而反应性淋巴结摄取减少。恶性病变的FDG摄取率似乎与肿瘤细胞与间质的摄取率有关。在这个系列中，作者发现FDG-PET是评估头颈部癌症患者的一种有用的诊断方式。

The positron emission tomography (PET) tracer 2-18F-fluoro-2-deoxy-D-glucose (FDG) is the most widely used tracer in oncology. This study was undertaken to evaluate PET in the detection of head and neck malignancies, compared to analysis of MRI,CT and histopathological findings.A total of 17 patients with malignant tumors were examined with FDG.PET revealed that each biopsy-proven primary lesion is an area of increased FDG uptake. Metastatic lymph node has been demonstrated in two cases by the pathologic findings. The smallest metastatic lymph node detected in the retropharyngeal space by FDG-PET was 4mm. The uptake of FDG in lymph nodes were studied from 10 to 60 min after a injection of FDG.Metastatic lymph node uptake increased gradually after injection, whereas reactive node uptake decreased. The FDG uptake ratio was seemed depend on the rate between tumor cells and interstitial tissue in malignant lesion. In this series, the authors found that FDG-PET is a useful diagnostic modality for evaluation the patient with head and neck cancers.