New Syntheses of Trifluoromethylethers and Trifluoromethylphosphines by Electrophilic Trifluoromethylation

生命科学工业越来越多地使用有机氟化合物。2005年一项针对200种最畅销处方药的调查显示，其中16%的化合物含有氟与碳的结合。该项目的目的是开发一种新的氧和磷亲核试剂三氟甲基化反应，同时考虑到这类反应仍然未知。因此，除了我们将要探索的化学毫无疑问存在的应用潜力之外，该项目还应该阐明有机分子反应性的基本方面。氧亲核试剂的三氟甲基化研究将用定义明确的催化剂（铁的半夹心化合物）进行，这些催化剂既容易形成烷氧酮配合物，又容易在三氟甲基醚的形成中进行单电子氧化。此外，我们计划系统地研究一系列仲膦亲电三氟甲基化的反应条件，以建立二茂铁基膦配体合成的一般路线。

The life science industry increasingly makes use of organofluorine com-pounds. A 2005 survey of the 200 best-selling prescription drugs reveals that 16 % of these compounds contain fluorine bound to carbon. The aim of this project is to develop a new reaction for the trifluoromethylation of oxygen and phosphorus nucleophiles, taking into consideration that such reactions are still unknown. Therefore, besides the undoubtedly existing application potential of the chemistry we are going to explore, there are also fundamental aspects of organic molecular reactivity the project should shed light on. The investigations for trifluoromethylation of oxygen nucleophiles will be done with well-defined catalysts (half-sandwich compounds of iron) able to both easily form alkoxylato complexes and undergo one electron oxidations under formation of trifluoro-methylethers. Furthermore, we plan systematic investigations of the reaction conditions for the electrophilic trifluoromethylation of a series of secondary phosphines in order to establish a general route for the synthesis of ferrocene-based phosphine ligands.