31P-MAGNETIC RESONANCE SPECTROSCOPY IN EVALUATING HEPATIC FUNCTION : A POSSIBLE APPLICATION IN DONOR ASSESSMENT IN DONOR ASSESSMENT PRIOR TO LIVER TRANSPLANTATION

磁共振波谱（MRS）是一种非侵入性的测量体内化学物质浓度的方法。31 P-MRS已被用于评估小动物离体器官的活性。在有限的临床应用中，尺寸限制已被排除。然而，最近研制的深度分辨表面线圈系统（Dress）已使全身磁共振成像（MRI）能进行~（31）P-MRS在猪中进行了三项初步31 P-MRS研究，应用全身MRI系统对犬和人进行了研究。在长期冷缺血过程中，猪肝脏中NAD+NADH/PI比值降低。氧合血再灌注后，犬肝脏中产生高能PI。在体31 P-MRS是一种辅助诊断，将来可能在肝硬化患者的评估中发挥重要作用。在有MRI设施的中心，在满足脑死亡标准并同意器官捐献后，可评估器官活力。

MAGNETIC RESONANCE SPECTROSCOPY (MRS) IS A NONINVASIVE METHOD OF MEASURING THE CONCENTRATION OF CHEMICAL SUBSTANCES IN VIVO.31P-MRS HAS BEEN USED TO ASSESS THE VIABILITY OF ISOLATED ORGANS IN SMALL ANIMALS.SIZE CONSTRAINTS HAVE RESULTED IN LIMITED CLINICAL APPLICATION.HOWEVER,THE RECENT DEVELOPMENT OF A DEPTH RESOLVED SURFACE COIL SYSTEM (DRESS) HAS ALLOWED THE PERFORMANCE OF 31P-MRS USING WHOLE BODY MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS.THREE PILOT 31P-MRS STUDIES WERE PERFORMED IN PIGS,DOGS AND HUMANS USING A WHOLE BODY MRI SYSTEM.THE NAD+NADH/PI RATIO IN PORCINE LIVERS DECREASED DURING PROLONGED COLD IS CHEMIA.HIGH ENERGY PI WAS PRODUCED IN CANINE LIVERS AFTER REPERFUSION WITH OXYGENATED BLOOD.IN VIVO 31P-MRS WAS PERFORMED CLINICALLY AND MAY IN THE FUTURE PLAY SOME ROLE IN THE ASSESSMENT OF PATIENTS WITH CIRRHOSIS.IN CENTERS THAT HAVE MRIFACILITIES,ORGAN VIABILITY MAY BE ASSESSED AFTER BRAIN DEATH CRITERIA HAVE BEEN SATISFIED AND CONSENT GIVEN FOR ORGAN DONATION.