Investigation on the racial difference on the cleft lip and/or palate development

我们已经进行了流行病学研究和动物实验，因此我们发现遗传因素对唇腭裂的发生有一定的影响。我们认为CLP与遗传有关。我们一直在研究CLP的原因和预防措施。这次，我们关注亚洲人群中CLP发病率与细胞增殖因素之间的关系，并合作进行了一项调查。因此，我们发现了CLP与基因相关的可能性，并继续进行了研究。我们已经在一次会议上报告了一部分结果，并正在提交一份关于这一调查的论文。日方：我们从人类支持的角度出发，在越南继续免费为患者进行检查和手术，而默里博士和卢博士则与我们合作分析了在爱荷华州采集的白人血液样本、越南血液样本和菲律宾血液样本。我们已在1997年9月于新加坡召开的第八届国际腭裂及相关颅面畸形大会上报告了部分结果。1997年9月，木下博士在爱荷华州大学，分析了亚洲患者的血液样本，特别是巨口症患者。美国方面：Murray博士前往菲律宾，收集了CLP患者的血液样本。我们从人类的角度出发，在那里免费为CLP患者进行手术。我们完成了我们的联合研究，现在正在向Genomics提交申请。

We have already carried out epidemiologic studies and experiments with animals, so that we have found that genetic factor has some influence on occurrence of cleft lip and/or palate. We believe that CLP is associated with heredity. We have been studying cause and measures for prevention of CLP. This time, we paid attention to relationship between incidence of CLP in Asian population and factor for cell proliferation, and collaborated a survey. Therefore, we found the possibility of relationship between CLP and gene and have continued to study. We have already reported a part of the results at a meeting and are submitting a paper on this investigation.Japanese side : We go on examining and operating patients free of charge from the standpoint of human support in Vietnam, while Dr. Murray and Dr. Lew analyzed Caucasian blood samples taken in Iowa, Vietnamese blood samples and Philippine blood samples in cooperation with us. We have already reported a part of the results at 8th International Congress on Cleft Palate and Related Craniofacial Anomalies, September, 1997, held in Singapore. Dr. Kinoshita has stayed in University of Iowa in September, 1997, and analyzed blood samples of Asian patients, especially patients of macrostomia.American side : Dr. Murray went to Philippine and collected blood from patients with CLP. We operated patients with CLP free of charge there from our human standpoint.We are submitting to Genomics since we have finished our joint research.