Research on Human Retrovirus as a Pathogenic Agents and its Treatment.

人类T淋巴细胞病毒I型（HTLV-I）与许多不同的临床疾病有关。为探讨htlv - 1相关疾病的发病机制，对携带htlv - 1的大鼠（HAM大鼠）和转染env-pX基因的大鼠（env-pX大鼠）进行了研究。1) HAM大鼠经过长时间的潜伏期发展为慢性进行性脊髓病。脊髓病是由基于少突胶质细胞凋亡的脱髓鞘引起的。小胶质细胞感染HTLV-I。病变脊髓细胞凋亡前高表达pX mRNA和tnf - α，低bcl-2.2 env-pX大鼠出现多种胶原血管和自身免疫性疾病。这些大鼠的外周T淋巴细胞大量表达CD80/86和icam - 1，对各种抗原有高反应。浸润病变器官/组织的T淋巴细胞为寡克隆。骨髓移植实验表明，至少有3种致病过程与疾病的发生有关。3) Ick启动子env-pX大鼠淋巴组织特异性表达pX mRNA。他们会发展成胸腺瘤，但直到现在才出现ATL。

Human T lymphocyte virus type I (HTLV-I) is associated with a number of diverse clinical disorders. To investigate the pathogenesis of the HTLV-I related disease, rats carrying HTLV-I (HAM rats) and those transgened with env-pX gene (env-pX rats) were investigated.1) HAM rats develop a chronic progressive myelopathy after long incubation periods. The myelopathy is caused by demyelination based on apoptosis of oligodendrocytes. Microglias were infected with HTLV-I.High expression of pX mRNA and TNF-alpha is observed before apoptosis in the diseased spinal cord, while low of bcl-2.2) env-pX rats develop a wide spectrum of collagen vascular and autoimmune diseases. Peripheral T lymphocytes of these rats express high amount of CD80/86 and ICAM-I showing high response to various antigens. The T lymphocytes infiltrated to the diseased organ/tissu were oligoclonal. Bone marrow transplantation experiments suggest that at least 3 types of pathogenic process are concerned to develop diseases.3) Ick promotor env-pX rats show lymphoid tissue specific expression of pX mRNA.They develop thymomas but not ATL until now.