Static exercise-induced increase in blood pressure in individuals with cervical spinal cord injuries

我们评估了颈脊髓损伤（SCI）受试者C6至C8水平的静态运动压力反应中涉及的传入和反射通路。在这些科目中。下行的脊上交感神经元和从收缩肌经髓质心血管中心到周围血管的传入通路受损。我们测量了7名SCI受试者和7名年龄匹配的健全对照者在肱二头肌持续收缩2分钟期间的平均动脉血压（MBP）、心率（HR）和血浆去甲肾上腺素（NE）、肾上腺素(E)、肾素活性、加压素、醛固酮和人心房钠肽的浓度。静态运动导致两种脊髓损伤（运动前；74.7）的MBP显著升高（P<0.05）。[) 2.2、静态锻炼；[qh] [qh][) 4.1 mmHg)和对照组(运动前；101.0 (]SY.+-。[) 4.2，静态运动；[qh] [qh][) 4.9 mmHg)。脊髓损伤患者运动时心率无变化，而对照组运动时心率增高（运动前；68.7），差异有统计学意义（P<0.05）。[) 3.8，静态运动；[qh] [qh][) 3.1次/分)。在整个实验过程中，脊髓损伤的激素水平无明显变化。基于脊髓损伤患者运动时MBP的显著升高，我们的研究结果表明，脊髓损伤受试者存在一个独立于心血管髓质控制中心的功能性心血管控制系统，该系统调节静态运动时的血压反应。

We evaluated the afferent and reflex pathways involved in the pressor response to static exercise in subjects with cervical spinal cord injuries (SCI) at C6 to C8 level. In these subjects.the descending supraspinal sympathetic neurons and afferent pathways from the contracting muscles to peripheral vessels via the medullary cardiovascular center are damaged. We measured the mean arterial blood pressure (MBP) , heart rate (HR) and plasma concentrations of norepinephrine (NE) , epinephrine (E) , renin activity, vasopressin, aldosterone and human atrial natriuretic peptide during a 2-min period of sustained contraction of biceps brachii muscle in 7 SCI subjects and 7 age-matched ablebodied control subjects. Static exercise resulted in a significant increase in MBP (P<0.05) in both SCI (pre-exercise ; 74.7 (]SY.+-。[) 2.2, static exercise ; 81.9 (]SY.+-。[) 4.1 mmHg) and control (pre-exercise ; 101.0 (]SY.+-。[) 4.2, static exercise ; 117.0 (]SY.+-。[) 4.9 mmHg). There was no change in HR during exercise in SCI,while HR increased (P<0.05) during exercise in control subjects (pre-exercise ; 68.7 (]SY.+-。[) 3.8, static exercise ; 76.0 (]SY.+-。[) 3.1 beats/min). There were no significant changes in the hormones in SCI throughout the experiment. Based on the significant rise in MBP during exercise in SCI,our results indicate the presence of a functional cardiovascular control system in SCI subjects, which regulates the pressor response to static exercise is independent of the cardiovascular medullary control center.