A study to elucidate the neural mechanism for the execution of voluntary movement in humans using magnetoencephalography electroencephalography, and evoked potentials

本研究旨在利用脑磁图（magnetoencephalography，MEG）研究人类自主运动对视觉刺激的反应机制。实验一，我们研究了MEG对不同视觉刺激（如运动和颜色）的不同反应。MEG对颜色变化的反应发生在200 ms左右，估计来自梭状回。与此相反，MEG对颜色变化的反应发生在200 ms左右。在视觉运动刺激下，脑磁图的反应发生在150 ms左右，推测其起源于人类的视觉运动区。接下来，我们研究了人类对视觉运动刺激执行动作的反应时与对相同刺激的磁反应之间的关系。结果表明，我们的被试似乎对人类视觉运动区的神经活动产生了反应。在视觉运动刺激下，脑磁图的反应发生在150 ms左右。在视觉运动刺激由潜伏期为64 ms的明显运动刺激引起的运动区域。在第三个实验中，我们通过改变刺激时间来改变视运动的平滑性，这些刺激的脑磁图反应强度的变化与主观运动质量的评定有关，结果表明视觉信息加工的结果在局部皮层的神经活动中得到了反映我们计划进行一项研究，以探讨当运动质量变化时，人类对表观运动刺激的反应时间和磁反应之间的关系。

This study was to elucidate the neural mechanism underling the execution of human voluntary movement in reaction to the visual stimuli using magnetoencephalography (MEG).In the first experiment, we investigated whether MEG can detect different responses to the different visual stimuli, such as motion and color.MEG response to the color change occurred at about 200 ms and was estimated to originate from the fusiform gyrus.In contrast, MEG response to the apparent motion stimuli occurred at about 150 ms and was estimated to originate from the visual motion area in humans.The next study was to investigate the relation between the human reaction time to execute motion in response to the apparent motion stimuli and the magnetic response to the same stimuli.The results indicated that our subjects seemed to respond to the neural activity in the human visual motion area caused by the apparent motion stimuli with the latency of 64 ms.In the third experiment, we varied the quality of smoothness of apparent motion by changing the stimulus timing.MEG responses to these stimuli showed their strength change related to the subjective rating of quality of motion.The results indicate that the result of visual information process is represented in the neural activities in a localized cortical area.We are planning to do a study to investigate the relation between human reaction time and magnetic response to apparent motion stimuli when the quality of motion is varied.