Assessment of the high resolution micro-gradiometer for its clinical application

高分辨率微梯度仪的临床应用评估

• 批准号: 09557057
• 负责人: KANEOKE Yoshiki
• 金额: $ 8.13万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09557057/
• 关键词: human brain; peripheral nerves; muscle; sensory system; micro-squid; magnetoencephalography; 体性感覚; 磁場測定; サル; 筋; 脳; 磁場計測; 臨床応用

We have developed the 12-ch micro-gradiometer to detect the magnetic field derived from various biological tissues which would not be able to be detected by a conventional magnetoencephalograph. Using this device, we first recorded the somatosensory evoked cortical field induced by the electrical stimulation on the median nerve of a human subject. The evoked magnetic field was about 10 time larger than that detected by the conventional magnetoencephalograph. The magnetic field induced by the peripheral nerve conduction current was also clearly detected by this system, which could not be possible for the conventional system. Although this system's S/N ratio was comparable as those of the conventional system, we comfirmed that this system has a potential to detect smaller magnetic field change with the higher spatial resolution due to the short distance between the sensor coil and the biological tissues.

我们研制了12通道微梯度仪，用于检测传统脑磁仪无法检测到的各种生物组织的磁场。利用该装置，我们首次记录了电刺激人体正中神经引起的体感诱发皮层场。诱发磁场比常规脑磁图仪检测到的磁场大10倍左右。该系统还可以清楚地检测到由周围神经传导电流引起的磁场，这是常规系统无法实现的。虽然该系统的信噪比与传统系统相当，但我们确认，由于传感器线圈与生物组织之间的距离较短，因此该系统具有检测更小磁场变化的潜力，具有更高的空间分辨率。

项目成果

Hoshiyama,M. et al.: "Peripheral nerve conduction recorded by a micro gradiometer system (micro-SQIUD) in humans"Neuroscience Letters. 272. 199-202 (1999)

星山，M.

M.Hoshiyama, R.Kakigi, and O.Nagata: "Peripheral nerve conduction recorded by a micro gradiometer system (micro-SQIUD) in humans"Neuroscience Letters. 272. 199-202 (1999)

M.Hoshiyama、R.Kakigi 和 O.Nagata：“微梯度计系统 (micro-SQIUD) 记录的人类周围神经传导”神经科学快报。

Hoshiyama,M. et al.: "Peripheral nerve conduction recorded by a micro-gradiometer system (micro-SQUID) in humans"Neuroscience Letters. 272. 199-202 (1999)

星山，M.