Studise on prolactin(PRL)secretion of premature and full-term neonates in normal and various pathological conditions.

1993年，我们研究了早产儿和正常新生儿围产期泌乳素分泌情况。自1996年以来，我们越来越多地研究了小日期、适当日期和大日期新生儿的催乳素分泌。我们还研究了各种中枢神经系统疾病患儿的催乳素分泌，如颅内出血、化脓性脑膜炎、热性癫痫、西综合征、癫痫和周期性ACTH-ADH放电综合征。在妊娠28 ~ 37周出生的早产儿中，血清催乳素随着妊娠周的增加而增加，在足月正常新生儿中达到最高水平。泌乳素在小日期、合适日期和大日期新生儿之间无显著差异，泌乳素作为生长因子的作用未得到证实。在足月窒息新生儿中，催乳素水平较高且持续时间较长，而在窒息早产儿中，催乳素水平与未窒息早产儿无显著差异，可能与下丘脑抑制催乳素的作用发育不成熟有关。在颅内出血和化脓性脑膜炎新生儿中，严重者血清催乳素升高。在癫痫性疾病中，血清催乳素在发作期间升高，在发作之间恢复正常。

In 1993, we studied prolactin secretion of premature and normal newborns in perinatal period. Since 1996, we have studied prolactin secretion of small-for date, appropriate-for date and large-fo-date newborns in increased number. We have also studied prolactin secretion of children with various central nervous system disorders, i.e. intracranial hemorrhage, purulent meningitis, febrile seizure, West syndrome, epilepsy and periodic ACTH-ADH discharge syndrome. In prematurenewborns born between 28 and 37 weeks of gestation, serum prolactin increased with increasing gestational weeks and reached at highest level in full-term normal neonates. There were no significant difference of serum prolactin between small-for-date, appropriate-for date and large-for date newborns and role prolactin as growth factor was not proved. In asphyxia of full-term neonates, prolactin levels were high and stayd high for longer period, however in asphyxia of premature neonates, prolactin did not show significant difference from premature neonates without asphyxia, probably due to immature development of prolactin inhibiting effect of hypothalamus. In intracranial hemorrhage and purulent meningitis neonates, high serum prolactin were observed in serious cases.In seizure disorders, serum prolactin increased during attacks and returned to normal between attacks.