Distribution and function of fibroblast growth factor in the retina and the epiretinal membrane.

眼部增生性疾病有很多，如增生性玻璃体视网膜病变、相关性黄斑变性、增生性糖尿病视网膜病变等。这是导致成人失明的主要原因。成纤维细胞生长因子（FGFs）可能与这些疾病的进展有关，FGFs的研究可能有助于治疗。在正常大鼠视网膜中，酸性FGF表达于视网膜色素上皮（RPE）、内丛状层和神经节细胞层。基本(b) FGF在各种视网膜细胞的细胞核中表达。据报道，细胞核中FGF的存在有助于细胞的增加，细胞核中bFGF可能是眼部增生性疾病。FGF-5存在于光感受器细胞内段，提示FGF-5维持了光感受器外段的更新。另一种眼部增生性疾病的生长因子可能是血管内皮生长因子（VEGF）。我们的研究揭示了VEGF在神经节细胞中的表达。VEGF可能有助于视网膜细胞的维持。在ARMD和PDR标本中，bFGF在色素细胞中表达。另一方面，FGF-5在ARMD维管膜内的血管内皮细胞中表达。提示FGF-5可能促进视网膜下血管膜的发育。随着ARMD数量的增加，抗fgf -5单克隆抗体可能是治疗ARMD的有效药物。

There are many ocular proliferative diseases such as proliferative vitreoretinopathy, agerelated macular degeneration, and proliferative diabetic retinopathy. which are major cause of adult blindness. Fibroblast growth factors (FGFs) may relate to progression of these diseases and the study of FGFs may contribute to the treatment.In the normal rat retina, acidic FGF was expressed in the retinal pigment epithelium (RPE), inner plexiform layr, and ganglion cell layr. Basic (b) FGF was expressed in the nuclei of various retinal cells. As it was reported that existence of FGF in the nucleus contributed to increase of cells, bFGF in the nucleus may ocular proliferative diseases. FGF-5 existed in the inner segment of photoreceptor cells, which suggest that FGF-5 maintain the renewal of photoreceptor outer segments. Another growth factor for ocular proliferative diseases may be vascular endothelial growth factor (VEGF). Our study reveal the expression of VEGF in the gangloin cells. VEGF may contribute to the maintenance of retinal cells.In the specimens of ARMD and PDR, and bFGF expressed in the pigment cells. On the other hand, FGF-5 expressed in the vascular endothelial cells in the ARMD vascular membrane. It may be suggested that development of subretinal vascular membrane is promoted by FGF-5. ARMD is increasing in number and anti-FGF-5 monoclonal antibody may be useful for the treatment of ARMD.