Unleashing the Hidden Chemical Diversity in Australian Fungi

该项目旨在开发由&gt；150种独特的澳大利亚丝状真菌组成的独家基因组资源，该资源是由大学和行业合作建立的，用于基因组指导的生物发现。这些真菌的基因组序列揭示了产生新的生物活性分子的广泛隐藏的遗传指令。该项目将应用尖端合成生物学和化学工具来挖掘这些澳大利亚真菌隐藏的基因组潜力。该项目的预期成果包括具有理想生物活性的新精细化学品和铅分子。这将通过发现新的药品、兽药产品和农用化学品为澳大利亚经济带来重大好处。

This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.