Epidemiological Investigation on CL/P and maternal environment - Attempt to prevent recurrence of CL/P -

1.我们开发了一个系统，以防止CL/P在日本的第一次临床尝试，并开始了流行病学调查的系统。本研究的目的之一是了解该系统是否能有效地预防CL/P。研究组织涉及日本18所大学的产科、口腔外科和营养学系。我们出版了一本关于孕期保健、营养和饮食的书，还介绍了先天性畸形、CL/P和其他因素，以提高准妈妈的认识。受试者均为计划怀孕，在改善母体环境后怀孕。我们建议采取均衡饮食，包括叶酸超过0.4mg/天，并控制危险因素，如药物，吸烟和酒精。她们在怀孕前拜访了产科医生，接受了包括血液检查在内的临床实验室检查，并根据她们的日常饮食记录接受了营养师的营养指导。我们从2000年10月开始实施这一系统，有28名受试者参加了这项研究。4名受试者分娩，4名受试者现在怀孕。我们会继续调查。

1. We developed a system to prevent CL/P for the first clinical attempt in Japan and started an epidemiological investigation by the system. One objective of this study was to see whether the system, improving the maternal environment before and during pregnancy, is effective in preventing CL/P. Research organizations involved the departments of obstetrics, oral surgery and nutriology of 18 universities in Japan.2. We published a book about care during pregnancy, nutrition and diet, and also about congenital anomalies, CL/P and other factors for improving the prospective mothers' understanding.3. Subjects were under planned pregnancy and they became pregnant after maternal environment had been improved. We recommended to take balanced diet including folic acid more than 0.4mg/day, and to control risk factors such as drugs, smoking, and alcohol. They visited an obstetrician before pregnancy, underwent clinical laboratory tests including a blood test, and received nutritional guidance from nutritionist based on their daily dietary records.4. We carried out this system from October 2000, with 28 subjects enrolled in the study. Four subjects gave birth and four subjects are now pregnant.5. We will continue the investigation.