New technique for recovering continuous distributions of ventilation as a function of ventilation/volume ratio from observed nitrogen washout curves to apply the sensitive health indicator.

用快速气体分析仪采集的多次呼吸N_2洗脱已被证明是分析肺功能的有力工具。在50个多隔室的基础上，用计算机对多次呼吸法获得的N_2冲刷曲线进行了数学分析。在本研究中，应探讨一种新的分析技术，以确定合适的权重系数，以评估肺内功能的亚临床不均一性。从观测的氮洗曲线恢复通气量随通气量/体积比变化的连续分布的新技术建立了基于最小二乘法的参数估计问题。为了平滑相邻通风相对于通风/体积比的差异，可以根据Akaike的ABIC(贝叶斯信息准则)从理论上定义平滑项的最佳权重。将该方法应用于心脏病患者，观察肺充血(和/或水肿)及肺血流量增加对肺内气体分布的影响。

The multiple breathing N_2 washout sampled by a rapid gas analyzer has proved to be a potent tool in the analysis of pulmonary function. N_2 washout curves obtained by a multiple breathing method were analyzed on the basis of 50 multiple compartments by means of a mathematical technic using a computer. In this research, it should be reported to approach a proposal of a new analyzing technique for the multiple breathing N_2 washout to take a suitable weighting coefficients and evaluate subclinical unevenness of intrapulmonary function. New technique for recovering continuous distributions of ventilation as a function of ventilation / volume ratio from observed nitrogen washout curves. A parameter estimation problem is formulated based on the method of least squares. To take smoothing the differences of neighboring ventilation with respect to ventilation / volume ratio, te optimum weight for the smoothing term can be theoretically defined according to Akaike's ABIC (A Bayesian Information Criterion). This method were applied on patients with heart diseases to investigate the effects of pulmonary congestion (and/or edema) and the increase of pulmonary blood flow on intrapulmonary gas distribution..