Comparative study of canine and human atopic dermatitis from immunological aspect

犬特应性皮炎被定义为一种遗传性的、ige介导的对环境过敏原的超敏反应。然而，治疗和管理人类特应性皮炎有时被认为是困难的，以及狗。本文从环境、临床和免疫学等方面探讨了犬特应性变态反应的临床模型。首先，采用问卷调查法收集2164例特应性皮炎犬患者的背景资料。在日本，易患特应性皮炎的犬种包括柴犬、狮子狗、金毛猎犬和西部高地白梗。日本特应性皮炎的主要过敏原包括屋尘螨、日本雪松和杂草花粉。可见，犬特应性皮炎主要受室内环境影响而非室外环境。特应性皮炎患者外周血淋巴细胞产生的Th2细胞因子（白细胞介素10和白细胞介素4）没有改变，然而，Th1细胞因子（γ干扰素）在特应性皮炎患者以及人类和小鼠中减少。这些结果可能导致结论，犬特应性皮炎可能是评估人类特应性治疗方面的一个很好的模型。

Canine atopic dermatitis is defined as a hereditary, IgE-mediated hypersensitivity to environmental allergens. Whereas, the therapy and management of human atopic dermatitis is sometimes thought to be difficult as well as dogs. We have investigated if canine atopy could be a clinical model in view of environmental, clinical and immunological aspect. Firstly, background data from 2,164 dog patients with atopic dermatitis were collected by a questionnaire study. Dog breeds predisposing atopic dermatitis in Japan included Shiba-inu, Shi-tzu, Golden retriever and West Highland white terrier. Major allergens in Japanese atopic dermatitis included house dust mites, Japanese cedar and weed pollen. It is conceivable that canine atopic dermatitis affects mainly from indoor environment rather than outdoor environment. Th2 cytokine production (interleukin 10 and 4) from peripheral lymphocytes of atopic dermatitis was not altered, however, Th1 cytokine (gamma interferon) was reduced in atopic patients as well as human and mice. These results might lead the conclusion that canine atopic dermatitis may be a good model for the assessment of a therapeutic aspect of human atopy.