Effect of Visual or Audition Rhythmic Stimulation on Cognitive Information Processing Speed in patients with Neurodegenerative Diseases.

在视觉注意任务中记录7个头皮部位的电生理活动，以研究刺激诱发的非同步（SOA）因素ERPs（事件相关电位）的影响。我们研究了9个健康个体的主要ERP组件和从恒定和随机SOA中减去的子组件。与随机条件相比，奇数反应范式（OBP）的N1、P2和P3潜伏期显著短，恒定条件下OBP的N1负偏转幅度和简单反应范式（SRP）的P1和P2正偏转幅度显著大。通过将频繁的非目标刺激的erp与SRP的erp相减，得到NA的差分波形。N2的差分波形是由频繁非目标刺激的erp减去OBP中罕见目标刺激的erp得到的。恒定条件下NA振幅的负偏转明显大于随机条件下。差异波形的N2分量无明显的SOA效应。实验结果表明，恒定条件下的视觉信息加工速度比随机条件下快，且加工速度更快。对于差异波形，我们发现NA幅值反映的模式识别加工受SOA条件的显著影响，相反，N2幅值反映的刺激分类加工受影响较小。

Electrophysiological activity was recorded at 7 scalp locations during visual attention task in order to investigate the effect of stimulus-onset asynchrony (SOA) factors ERPs (event-related potentials). We investigated main ERP components and subcomponents derived from subtraction on both constant and random SOA in 9 healthy individualities. Comparted to random condition, the latencies of N1, P2 and P3 of oddball paradigm (OBP) were significantly short, and Negative deflection of N1 amplitude of OBP and positive deflection of P1 and P2 amplitude of simple reaction paradigm (SRP) were significantly large under constant condition. Difference wave form of NA was derived by subtracting the ERPs of SRP from those of the frequent nontarget stimuli of OBP. Difference wave form of N2 was derived by subtracting the ERPs of frequent nontarget stimuli from those of the rare target stimuli in the OBP. Negative deflection of NA amplitude was significantly larger for constant than for tandom condition. No significantly SOA effect was found on N2 component of difference waveform. These results suggest that the visual information processing was fast and increased under constant than random condition. As for the difference waveform, we conclude that pattern recognition processing reflected by NA amplitude was signigicantly influenced by SOA condition, conversely, stimulus classification processing reflected by N2 amplitude was little influenced.