ESTABLISHMENT OF A NOVEL THERAPY INCLUDING MILD HYPOTHERMIA AGAINST ACUTE ENCEPHALOPATHY IN CHILDREN

急性脑病是一种严重的儿科疾病，其病理生理机制尚不清楚，现已知其相关因素之一是流感病毒感染。流感感染可导致血脑屏障功能障碍和多种细胞因子的异常产生，继而导致神经细胞的大量死亡。本病的治疗策略是防止疾病的级联反应。此外，我们报道了传统疗法对该病的疗效有限。我们试图建立包括亚低温和甲基强的松龙脉冲疗法的新疗法，以改善DISEAS患者的预后。我们分析了35例急性脑病患者在常规治疗下的精确资料。结果为差。10例死亡。1例严重生活残疾。1例轻度痴呆。我们建立了一种新的治疗方法，包括亚低温和甲基强的松龙联合治疗急性脑病和/或脑炎。到目前为止，我们应用这种治疗方法对10例患者进行了治疗。结果表明，这种治疗方法的结果似乎比传统方法好。现在就断定这种新疗法的疗效还为时过早。我们认为这种新疗法是PROMISG，NOW为了建立治疗方法，我们必须确定应用治疗的患者的A标准，以及增加治疗的患者数量。

ACUTE ENCEPHALOPATHY IS ONE OF SEVERE DISORDERS IN CHILDHOOD.ALTHOUGH, IT'S PATHOPHYSIOLOGY REMAINS UNKNOWN, IT IS NOW KNOWN THAT ONE OF RELATED FACTORS IS INFLUENZA VIRUS INFECTION.THE INFLUENZA INFECTION MIGHT INDUCE THE FAILURE OF BLOOD-BRAIN BARRIER AND THE ABNORMAL PRODUCTION OF SEVERAL CYTOKINES, FOLLOWED BY THE MASSIVE DEATH OF NEURONS.THEREFORE, THE STRATEGY TO TREAT THE DISEASE IS TO PREVENT THE CASCADE OF THE EVENTS.IN ADDITION, WE REPORTED THAT THERE WAS A LIMITED EFFICACY IN THE DISEASE WITH THE CONVENTIONAL THERAPIES.THEREFORE, WE TRY TO ESTABLISH A NOVEL THERAPY INCLUDING MILD HYPOTHERMIA AND METHYLPREDNISOLONE PULSE THERAPY TO IMPROVE THE OUTCOME OF THE PATIENTS WITH THE DISEASE.BEFORE STARTING THE NEW THERAPY, WE ANALYZED THE PRECISE DATA OF 35 PATIENTS WITH ACUTE ENCEPHALOPATHY UNDER THE CONVENTIONAL THERAPY.THE OUTCOME WAS BAD.THAT IS, 10 PATIENTS WERE DEAD.ONE THIRD HAD SEVERE DISABILITY IN DAILY LIFE.ONE THIRD HAD MILD DISABILITIES.WE ESTABLISHED A NOVEL THERAPY INCLUDING MILD HYPOTHERMIA AND METHYLPREDNISOLONE COMBINATION AGAINST ACUTE ENCEPHALOPATHY AND/OR ENCEPHALITIS.SO FAR WE APPLIED THIS THERAPY TO 10 PATIENTS.IT SEEMS THAT THE OUTCOMES OF THE PATIENTS WITH THIS THERAPY BECOME BETTER THAN THOSE WITH CONVENTIONAL THERAPY.IT IS TOO EARLY TO CONCLUDE THE EFFICACY OF THIS NEW THERAPY.HOWEVER, WE BELIEVE THAT THIS NOVEL THERAPY IS PROMISING.NOW, TO ESTABLISH THE THERAPY WE HAVE TO DETERMINE A CRITERIA OF THE PATIENTS TO APPLY THE THERAPY AS WELL AS TO INCREASE THE NUMBER OF THE PATIENTS WITH THE THERAPY.