Research for the development of foreseeing and early diagnosis for hepatic metastasis from digestive cancer

消化道肿瘤的转移对其预后有重要影响。特别是对肝转移的改善是迫切需要的。然而，肝脏中非常小的转移性病变已经能够通过医学成像方式检测到，如果更小的病变被检测到，治疗效果将会提高。如果发现肝转移灶大小不可见，化疗后使用抗血管生成药物或抗癌药物可完全缓解。本研究的目的是利用正电子发射断层扫描检测肝脏血管生成引起的血流变化，从而发现肝脏中不可见的转移性病变。结果：动物模型肝转移灶动脉血流增加，门静脉血流减少。采用H_2^<15>O注射动态正电子发射断层扫描法测定晚期结直肠癌患者的肝血流。采用H_2^< 15b> O注射动态正电子发射断层扫描法测定结直肠癌肝转移患者的肝血流。肝动脉血流增加，门静脉血流减少。证明利用正电子发射断层扫描检测动脉和门静脉血流的变化是可以早期发现的

Metastasis of the digestive cancer is very important for prognosis of the disease. In particular, the improvement of hepatic metastasis is urgently needed. However the very small metastatic lesion in the liver has been able to detect by medical imaging modalities, if smaller size of lesion is detectable, treatment effect will improve. If invisible size of hepatic metastasis is detected, complete remission will be given after chemotherapy using anti-angiogenetic drugs or anti-cancer drugs. Aim of this research is the detection of invisible metastatic lesion in the liver by detecting the blood flow change in the liver due to angiogenesis using positron emission tomography. As results,Increase in arterial blood flow and decrease in portal blood flow were detected in the liver with metastasis using animal model.Hepatic blood flow was measured in patients with advanced colorectal cancer using H_2^<15>O bolus injection dynamic positron emission tomography study as control.Hepatic blood flow was measured in patients with colorectal hepatic metastasis using H_2^<15>O bolus injection dynamic positron emission tomography study. And, increase in arterial blood flow and decrease in portal blood flow were detected in the liver.It was proved that early detection was possible by detecting the change of arterial and portal blood flow using positron emission tomography