Central control and adaptive mechanisms in vergence eye movement

关于趋同眼动的神经机制，特别是与适应有关的知识仍然很少，而不是近十年来的努力。在这项研究中，我对会聚和相关的眼动进行了心理物理和脑成像研究。在心理物理研究中，1)利用计算机辅助立体刺激的双步范式发现了趋同和追求的适应性变化。用红外眼缘追踪仪监测眼球运动；2)分析了运动背景对中心目标引起的收敛的影响。(投资。Ophthalm。粘度科学。， 2001；视觉研究，2001；投资。Ophthalm。自然科学，2001)。在PET研究中，通过带有眼动监视器的立体头戴式显示器给予立体刺激。V5，顶叶下回、枕侧回和梭状回被激活（NeuroImage, 1999）。fMRI研究显示，小脑在蚓部（VI和VII）和半球的激活。基于这些结果，我们认为是运动指令发生器，而不是视觉-运动整合位点，导致了眼球运动的自适应变化。

The knowledge on neural mechanisms of vergence eye movement, especially in relation to adaptation, is still poor, instead of efforts in the last decade. In this study, I performed psychophysical and brain imaging studies on vergence and related eye movements. In psychophysical studies, 1) adaptive changes in vergence as well as pursuit were found by double step paradigm using computer-assisted stereoscopic stimuli. Eye movement was monitored by an infrared limbus tracker ; and 2) effects of the moving background on vergence evoked by a central target were analyzed. (Invest. Ophthalm. Vis. Sci., 2001 ; Vision Research, 2001 ; Invest. Ophthalm. Vis. Sci, 2001). In PET studies, stereoscopic stimuli were given through a stereoscopic head-mounted display with an eye movement monitor. V5, inferior parietal, lateral occipital and fusiform gyri were activated (NeuroImage, 1999). In fMRI studies, cerebellar activation in vermis (VI and VII) and hemisphere were revealed. Based on these results, it is indicated that the motor command generators, rather than the sites for visuo-motor integration, are responsible for adaptive changes in vergence and pursuit eye movements.