EVALUATION FOR ANIMAL MODEL OF WONDERER IN TRANSIENT ISCHEMIA-INDUCED ABNORMAL BEHAVIOR

可以想象，精神障碍的危象和加重与应激、酒精等诱发脑内某些神经递质异常的发生有关，抑郁症的发生被认为是由于脑内5-羟色胺作为一种倾向性减少，导致突触后5-羟色胺2受体变得超敏。提示应激时，5-羟色胺过度释放，诱发抑郁。另一方面，众所周知，双侧颈动脉闭塞5分钟诱导蒙古沙土鼠海马CA 1区神经元迟发性神经元死亡。除此现象外，沙鼠在神经元死亡之前还发生持续的过度活跃（异常行为）。短暂性脑缺血可引起某些神经递质的异常释放，从而诱发持续性的异常行为障碍。很明显多巴 ...更多信息 矿物质神经递质系统与持续性异常多动有关。因为，当多巴胺能受体拮抗剂在短暂缺血后24小时给药时，缺血诱导的多动性是最显著的时期，缺血诱导的多动性被显著抑制。在蒙古沙鼠中检查了重复给予抗抑郁药和甲基苯丙胺（MAP）对缺血诱导的多动性的影响，因为众所周知，抗抑郁药和MAP的作用通过重复给予这些药物而加强。丙咪嗪（5和10 mg/kg）、阿托咪嗪（5 mg/kg）、帕罗西汀（5 mg/kg）和MAP（1和3 mg/kg）每天给药一次，持续7或14天。在最后一次给药后30 min，闭塞双侧颈动脉。在缺血后3和24小时测量自发活动。MAP剂量依赖性地抑制脑缺血引起的多动性，而丙咪嗪、地昔帕明和帕罗西汀对多动性无影响，提示脑缺血引起的多动性与多巴胺能神经传递有关。多巴胺能神经系统阻滞剂似乎是治疗脑血管疾病后遗症之一的游荡最有效的药物。少

It is conceivable that the crisis and exacerbation of the psychiatric disorder is related to the occurrence of abnormality of some neurotransmitters in the brain, which are induced by stress, alcohol and so on. The depression has been supposed that the postsynaptic serotonin 2 receptor becomes for the supersensitivity, because of the decrease of serotonin in the brain as a disposition. It is suggested that when stresses are taken, serotonin over release is happened and the depression is induced. On the other hand, it is well known that the occlusion of bilateral carotid arteries for 5 min induces delayed neuronal death in the hippocampal CA1 neurons in Mongolian gerbils. In addition to this phenomenon, sustained hyperactivity (abnormal behavior) is happened prior to the neuronal death in gerbils. The abnormal release of some neurotransmitters are happened by the transient cerebral ischemia, and this seems to induce the sustained abnormal behavior disorder. It became clear that the dopa … More minergic neurotransmitter system was related to the sustained abnormal hyperactivity. Because, when dopaminergic receptor antagonists were administered 24 hr after transient ischemia, in which ischemia-induced hyperactivity was most remarkable period, ischemia-induced hyperactivity was inhibited significantly. The effect of repetitive administration of antidepressants and methamphetamine (MAP) on ischemia-induced hyperactivity was examined in Mongolian gerbils, because it is well known that the action of antidepressants and MAP is strengthened by the administration of these drugs repeatedly. Imipramine (5 and 10 mg/kg), desiramine (5 mg/kg), paroxetine (5 mg/kg), and MAP (1 and 3 mg/kg) were administered for 7 or 14 days once a day. Bilateral carotid arteries were occluded 30 min after the last administration of these drugs. The locomotor activity was measured 3 and 24 hr after ischemia. Though the hyperactivity induced by cerebral ischemia was suppressed by the administration of MAP dose dependently, imipramine, desipramine and paroxetine has no effect on it. From these results, it is conceivable that ischemia-induced hyperactivity is related to the dopaminergic neurotransmission. Dopaminergic nervous system blocking agents would seem to be the most effective for wandering which is one of the cerebrovascular disorders sequela. Less