How do protein quality control mechanisms maintain neuronal ageing?

该项目旨在研究蛋白质质量控制机制如何在大脑中发挥作用-大脑是一个特别容易受到高负荷错误折叠蛋白质影响的器官-以维持衰老过程中的正常生理机能。该项目预计将在细胞生物化学和神经科学方面取得进展，使用创新的邻近标记方法来识别神经元中的质量控制调节剂，这些调节剂在活体动物的神经系统中，在衰老过程中专门与错误折叠的蛋白质结合。该项目的预期成果将产生与所有动物相关的脑生理学和衰老的新知识。这应该会带来显著的好处，比如更好地理解包括记忆在内的长期大脑功能。

This project aims to interrogate how mechanisms of protein quality control act in the brain - an organ that is particularly vulnerable to a high load of misfolded protein - to maintain normal physiology during ageing. This project expects to make advances in cellular biochemistry and neuroscience, using an innovative proximity labelling approach to identify quality control regulators in neurons that specifically engage with misfolded proteins during ageing, within the nervous system of a living animal. Expected outcomes of this project will generate new knowledge of brain physiology and ageing relevant to all animals. This should provide significant benefits, such as a greater understanding of long-term brain functions including memory.