Advanced Chemical Protein Synthesis and Applications

该项目旨在开发用于肽、寡核苷酸和蛋白质的化学组装的增强方法。这将导致化学和结构生物学的新知识的创造，并支持药物发现过程，制药和生物催化的进步。一旦完成，预计将随之产生更低成本，更环保的生产药物，如恩夫韦肽（用于艾滋病毒）的过程。还将开发新一代超稳定、环境友好的催化剂。这可以使精细化学品和基本药物的国内生产成为可能，从而在一个更加多样化、更具弹性的经济中创造高科技就业机会。最终，它可以改善人类健康的结果。

This project aims to develop enhanced methods for the chemical assembly of peptides, oligonucleotides and proteins. This will lead to the creation of new knowledge in chemistry and structural biology, and underpin advances in the drug discovery process, pharmaceutical manufacture and biocatalysis. Once complete, it is expected that lower cost, greener processes for manufacturing drugs such as Enfuvirtide (for HIV) will ensue. A new generation of hyper-stable, environmentally friendly catalysts will also be developed. This could enable domestic production of fine chemicals and essential medicines, and thus create high-tech jobs in a more diversified, resilient economy. Ultimately, it could lead to improved outcomes in human health.