Multiscale mathematical modelling to gain insights into hepatitis viruses

该项目旨在利用数学模型在多个层面上研究肝炎病毒。该项目希望开发复杂但可分析的数学模型，通过在细胞内和细胞水平阐明病毒和免疫标志物的纵向模式来理解肝炎病毒的基本生物学，并在数学生物学中推进一个新的子领域，即对相互依赖的人类病毒进行建模。该项目的预期成果包括新的通用数学工具、可能有助于超出该项目范围的研究的生物学见解，以及强有力的跨学科合作。预期的好处包括澳大利亚研究界在病毒学中使用数学模型的能力增加。

This project aims to use mathematical modelling to study hepatitis viruses at multiple levels. The project expects to develop complex yet analysable mathematical models to comprehend the fundamental biology of hepatitis viruses by elucidating longitudinal patterns in viral and immune markers at intracellular and cellular levels, and advance a new subfield in mathematical biology, i.e., modelling codependent human viruses. Expected outcomes of the project include new generalized mathematical tools, biological insights that may aid research beyond the scope of this project, and strong interdisciplinary collaborations. Expected benefits include an increased capacity of the research community in Australia to use mathematical models in virology.