Interrogating the adaptive potential of skeletal muscle

肌肉氧化能力和生长能力的中断是随着年龄的增长而导致的萎缩和功能障碍的基础，这会影响个人的生活质量。这些生物过程被认为是相互排斥的，在肌肉适应过程中相互竞争。该项目旨在确定这些过程如何调节肌肉适应的程度，以及改变这些属性如何影响衰老背景下的功能能力。这个项目将提供基本的新知识来理解肌肉属性的改变如何影响成功的衰老。这些知识将提高所有澳大利亚人的韧性、生产力和幸福感，并对减轻社会和经济负担产生影响。

Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. This project will provide fundamental new knowledge in understanding how modifying muscle attributes influence successful ageing. This knowledge will improve resilience, productivity, and wellbeing of all Australians, with implications for reducing societal and economic burden.