Determining the regulation of ovary development with single cell sequencing

该项目将极大地促进我们对卵巢发育和哺乳动物生殖的了解。我将研究卵巢原始卵泡激活的过程，包括它的遗传调节，支持颗粒细胞的重要性以及调节因子的生物学意义。这将通过对卵巢发育的单细胞转录数据集(目标1)结合功能研究(目标2)进行全面调查来实现。其结果将通过提高牲畜生产力和控制入侵有害生物物种的新战略，对动物繁殖产生重大好处。这些成果具有经济和环境效益，对全国都有好处。

This project will greatly advance our understanding of ovary development and mammalian reproduction. I will investigate the process of ovarian primordial follicle activation including its genetic regulation, the importance of supportive granulosa cells and the biological significance of regulatory factors. This will be achieved through the comprehensive investigation of a single cell transcriptomic dataset of ovarian development (Aim 1) in conjunction with functional studies (Aim 2). The outcomes of which will hold significant benefit to animal reproduction through new strategies to improve livestock productivity and control invasive pest species. These outcomes are of economic and environmental and benefit nationally.