Molecular physiology of TRP channels induced via activation of metabotropic receptors

来自周围细胞外环境的细胞刺激通过质膜受体等机制诱导Ca^<2+>-渗透性阳离子通道的激活，形成控制生物反应的重要信号通路。了解这些阳离子通道（被称为受体激活阳离子通道（RACC））的分子机制的重要线索，只有通过研究瞬时受体电位（trp）蛋白（trp）才能提供，trp蛋白控制果蝇光感受器细胞中光诱导的阳离子电流。利用遗传信息和重组表达技术，已经发现了许多哺乳动物的TRP同源物。这进一步导致了新的RACC_s的鉴定。在会议上，我将介绍我们在研究哺乳动物RACC_s方面的最新进展，揭示1)TRP1在ny诱导的Ca^<2+>释放和储存操作的Ca2+进入中的关键参与，2)TRP6在平滑肌细胞中作为α_1-肾上腺素能受体激活的阳离子通道的鉴定，以及3)氧化系统与trp相关通道激活之间的重要相互作用。因此，trp相关通道被揭示为理解重要的生理反应和发明新的药物靶点的有力工具。

Cellular stimulation from the surrounding extracellular environment via mechanisms including plasma membrane receptors induces activation of Ca^<2+>-permeable cation channels that form essential signaling pathways in controlling biological responses. An imp ortant clue to understand the molecular mechanisms underlying these cation channels (termed as receptor-activated cation channels (RACC)) was only provided through studies of the transient receptor potential (trp) protein (TRP), which controls light-induced cationic currents in Drosophila photoreceptor cells. By using the genetic information and recombinant expression technique, numerous mammalian TRP homologues have been discovered. This further lead to identification of novel RACC_s. In the session, I would like to introduce our contribution to the recent dramatic progress in investigating mammalian RACC_s, revealing 1) critical involvement of TRP1 in both nyinduced Ca^<2+> release and store-operated Ca2+ entry, 2) identification of TRP6 as α_1-adrenergic receptor-activated cation channels in smooth muscle cells, and 3) essential interaction between redoxsy stem and TRP-related channel activation. Thus, TRP-related channels are revealed to be a powerful tool in understanding important physiological responses and for the invention of novel pharmaceutical targets.