Ca2+ signal generation in gonadotropes (A18)

促性腺激素 (A18) 中 Ca2 信号的产生

• 批准号: 234060417
• 金额: --
• 依托单位: FR Experimentelle und Klinische Pharmakologie und Toxikologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/234060417?language=en
• 关键词: Ca2+; signal; generation; gonadotropes; A18

Gonadotropes in the anterior pituitary gland control mammalian reproduction. We show that female murine gonadotropes display spontaneous [Ca2+]i oscillations during the luteinizing hormone surge, which triggers ovulation. The [Ca2+]i signals arise through cyclic transformation of these cells into a readily excitable state before ovulation and depend on voltage-gated Ca2+ channels, which are upregulated prior to the LH surge. In the next funding period, we want to dissect the molecular mechanisms underlying cyclic transformation of gonadotropes, extend our analyses of the gonadotrope cell network and investigate intraorganellar Ca2+ dynamics and hormone release in these cells.

垂体前叶中的促性腺激素控制哺乳动物的生殖。我们发现，雌性小鼠促性腺激素显示自发的[Ca2+]i振荡过程中的促黄体激素激增，从而触发排卵。[Ca2+]i信号通过这些细胞在排卵前周期性转化为易兴奋状态而产生，并依赖于电压门控Ca2+通道，该通道在LH峰之前上调。在下一个资助期，我们希望剖析促性腺激素循环转化的分子机制，扩展我们对促性腺激素细胞网络的分析，并研究这些细胞中细胞器内Ca2+动力学和激素释放。