The Study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias from the perspective of abnormal cytoskeletons

从细胞骨架异常的角度对非阿尔茨海默病的发病机制进行了研究。路易体痴呆的细胞病理学和临床病理研究一直是研究的热点。在细胞病理学研究中，采用α-突触核蛋白免疫组织化学方法观察路易小体的形成过程或退变过程。在轴突运输受阻的异常细胞骨架中，α-突触核蛋白积聚形成路易小体，并伴随神经胶质和免疫反应变性。在临床病理研究中，将路易氏病理从I期分级到IV期，并根据路易氏病理或阿尔茨海默病的严重程度将尸检病例分为若干亚型。在额颞叶痴呆(FTD)中，匹克病(Pick‘s disease，PID)分为两种类型：泛素性痴呆和泛素性痴呆。

The study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias has been performed from the perspective of abnormal cytoskeletons. Cytopathological and clinicopathological studies of dementia with Lewy bodies (DLB) have been focused. In the cytopathological studies, formation process or degeneration process of Lewy bodies was investigated using α-synuclein immunohistochemistry. Lewy bodies were formed by the accumulation of α-synuclein in the abnormal cytoskeletons with axonal transport blockage, and degenerated with glial and immunological reaction. In the clinicopathological studies, Lewy pathology was graded from stage I to stage IV, and autopsied cases of DLB were classified into some subtypes according to the degree of Lewy pathology or Alzheimer pathology. In frontotemporal dementia (FTD), Pick's disease (PiD) was divided into two types of tauopathy and ubiquitinopathy.