Experimental and Clinical Studied for process of gastric carcinogenesis

本研究对幽门螺杆菌（Helicobacter pylori，Hp）在胃癌发生过程中的作用进行了研究，取得了以下结果.在蒙古沙鼠（MG）模型中，Hp和化学致癌物可诱发多种胃癌表型，但肠上皮化生可能仅是一个亚组的胃癌的直接前体.在Hp与胃癌发生的关系中，Hp是一种促进剂而非引发剂，其他环境因素（致癌剂给药时机）也起重要作用. Hp感染+胃反流可促进MG模型胃粘膜细胞增殖.根除Hp可降低Hp感染对MG腺胃癌发生的促进作用。根除Hp可能是预防胃癌的有效方法。在Hp感染早期，胃粘膜内PGE2的升高和腺粘液细胞粘蛋白的分泌增加对坏死因子引起的胃粘膜损伤具有保护作用.结果表明，幽门螺杆菌感染时幽门粘膜中α 4GnT mRNA的表达水平有增加的趋势，提示幽门螺杆菌感染促进了腺粘液细胞型粘蛋白的生物合成。

The process of gastric carcinogenesis concerning Helicobacter pylori ( Hp ) was studied, and following results were obtained.1. In Mongolian gerbil ( MG ) model Hp and chemical carcinogen induce several phenotype of gastric cancer, but intestinal metaplasia may be a direct precursor only in a subset of the intestinal-type tumors.2. In the relationship between Hp and gastric carcinogenesis, Hp is a promoter rather than an initiator, and other environmental factors ( the timing of carcinogen administration ) play important roles.3. Hp infection plus duodenogastric reflux increase cell proliferation in the gastric mucosa in MG model.4. Hp eradication diminishes enhancing effect of Hp infection on glandular stomach carcinogenesis in MGs. Hp eradication may be useful as a prevention approach against stomach cancer.5. In the early stage of Hp infection, accentuation of intramucosal PGE2 and hypersecretion of mucin from gland mucus cells have a protective effect against gastric mucosal injury induced by necrotizing agents.6. As results, the expression level of a 4GnT mRNA tended to be increased in the pyloric mucosa with Hp infection, suggesting that Hp infection enhances the biosynthesis of gland mucous cell-type mucin.