Central genotyping services, coordination and quality control

该研究小组的项目正在寻求一种系统的方法来识别疾病基因。这种方法针对病因学的遗传成分，被称为位置克隆。一个成功的定位克隆在很大程度上依赖于高通量基因分型的高标准，因为大量精确的基因分型是重要的。对于雄心勃勃的项目的潜在失败，微小的错误率是可以接受的。在研究组内部，Q2项目协调所有高通量基因分型工作，并实施所有质量控制和会计措施。数据质量和资源分配的问题也相应地得到了解决和平衡。相关的组织结构被分配到第二季度。相关软件和计算工具也由Q2开发和部署。与柏林、基尔和慕尼黑的基因鉴定中心的密切合作将继续下去。

The projects of the research group are pursuing a systematic approach towards the identification of disease genes. This approach targets the genetic component of the etiology, and is known as positional cloning. A successful positional cloning heavily depends on high standards in high-throughput genotyping, since massive amounts of precise genotypes are instrumental. Minor error rates are amenable for potential failure of ambitious projects. Within the research group, project Q2 coordinates all high-throughput genotyping efforts and implements all measures of quality control and accounting. Problems of data quality and of resource allocation are addressed and balanced accordingly. The pertinent organizational structures are allocated to Q2. Relevant software and computational tools are developed and deployed by Q2, too. The close cooperation with the genotyping centers in Berlin, Kiel, and Munich is to be continued.