Pharmaceutical activity of ubiquinone analogs

合成了新的烷基- 1,4 -萘醌和烷基硫代或芳基硫代2,6 -二甲基- 1,4 -苯醌作为泛醌类似物，并测试了它们对呼吸链系统和牛心脏线粒体（BHM）脂质过氧化的影响。这些醌类化合物对BHM呼吸系统的抑制作用较弱。这些醌类化合物中有几种化合物作为外源性泛素-10有效地抑制脂质过氧化。研究了其在正己烷中对过氧自由基的化学反应性，并通过与N， N'-二苯基-对苯二胺的竞争来评价其在正己烷中氧化亚油酸甲酯的抗氧化能力。通过氧化速率降低的程度和抑制期的持续时间来评估效力。

New alkyl-l, 4-naphthoquinone, and alkylthio- or arylthio-2, 6-dimethyl-l, 4-benzoquinone as ubiquinone analog were synthesized and tested for the effect on the respiratory chain system and lipid peroxidation in bovine heart mitochondria (BHM). These quinones showed weak inhibitory activities on the respiratory system in BHM. The several compounds of these quinones were efficient as exogenous ubiquinone-10 for the inhibition of lipid peroxidation. The chemical reactivity toward peroxy radicals was investigated in n-hexane, and assessed by in the competition with N, N'-diphenyl-p-phenylenediamine and their antioxidant potency was evaluated in the oxidation of methyl linoleate in hexane. The potency was assessed by the extent of the reduction in the rate of oxidation and duration of inhibition period.