Pharmacological investigation of roles of cyclic flow reductions in the development of cerebral infarction

动物模型中可重复观察到循环流量减少的情况尚未见报道。因此，我们尝试建立脑循环循环血流减少的新模型。我们利用光化学血栓形成技术建立了模型，该技术是我们研究所开发的。利用该模型，我们研究了循环血流减少在脑梗死发展中的作用。抗血栓药物和溶栓药物对脑出血胎儿有副作用。然而，脑出血的发病机制尚不清楚，无法预测。虽然循环血流减少被认为与脑出血有关，但其机制尚不清楚。因此，我们研究了肝素这种抗血栓药物引起脑出血的机制。在兔脑血栓模型中，肝素引起脑出血，进而加重神经系统症状。一种根治性清除剂抑制肝素引起的脑出血，减少脑梗死面积。基于这些发现，自由基可能在脑出血中起关键作用。虽然自由基可损伤血管壁引起脑出血，但仍需进一步研究。

Animal models in which cyclic flow reductions are reproducibly observed have been not reported. Therefore, we tried to establish a new model with cyclic flow reductions in cerebral circulation. We establish the model using photochemical thrombosis technique, which has been developed in our institute. Using this model, we investigated roles of cyclic flow reductions in the development of cerebral infarction. Antithrombotic agents and thrombolytic agents have fetal side effects of cerebral hemorrhage. However, mechanisms of cerebral hemorrhage is still unclear and the predict is impossible. Although cyclic flow reductions are thought to contribute to cerebral hemorrhage, the mechanisms is unclear. Therefore, we investigated by what mechanisms heparin, an antithrombotic agent causes cerebral hemorrhage. In the rabbit cerebral thrombosis model, heparin caused cerebral hemorrhage and then worsen neurological symptoms. A radical scavenger inhibited cerebral hemorrhage produced by heparin and reduced cerebral infarct size. Based on these findings, free radical may play a key role in cerebral hemorrhage. Although free radical may damage vessel wall and then cause cerebral hemorrhage, further investigate may be required.