The role of ADP receptor (P2Y12) in the development of transplant arteriosclerosis

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The role of ADP (P2Y12) receptor on smooth muscle like cells (SMLCs) in the development of transplant arteriosclerosis (TA) was examined. A stable ADP analog, 2-methylthio-ADP-induced cell migration was significantly decreased in P2Y 12-deficient-SMLCs. In addition, the migration was significantly decreased by the pretreatment with wortmannin (phosphoinositide 3-kinase [PI3K] inhibitor) or PD98059 (extracellular signal-regulated kinase [ERK] inhibitor). However, the differentiation of bone marrow-derived cells into SMLCs was not associated with P2Y12 receptors. Thus, the migration of SMLCs mediated by P2Y12 receptors may play an important role in the development of TA, via PI3K-Akt and ERK signaling pathways.