Comparative study of hippocampal functions

本研究项目的目的是对海马功能进行比较研究。因此，该项目由6个研究小组组成，分别是鱼、鸟、老鼠、猴子和人类小组。鱼类研究小组为鱼类发明了一种类似莫里斯迷宫的迷宫，并明确了其端脑背内侧部分具有海马功能。鸟类研究小组发现，伊博tenic酸对鸽子海马形成的部分损伤不会导致空间学习的缺陷，但会导致整个损伤。大鼠研究小组检查了归巢任务，发现海马损伤后归巢任务受损。伊博tenic酸对大鼠CA1的选择性损伤导致Morris迷宫任务的缺陷。猴子研究小组证实了猴子缺血后的功能分离。人类研究小组还观察到海马损伤患者记忆任务中的功能性分离。2004年，我们在庆应大学举办了“海马体比较研究”国际研讨会。本次研讨会的论文将作为《神经科学评论》杂志的特刊发表。

The purpose of this research project is comparative study of the hippocampal function. Thus, the project consisted of six research teams, namely fish, bird, rat, monkey and human teams. The fish team invented a maze similar to Morris maze for fish and clarified that its dorsomedial part of telencephalon has a hippocampal function. The bird team showed partial lesions in the hippocampal formation by ibotenic acid did not cause deficits in spatial learning in pigeons but whole lesions did. The rat team examined homing task and found impairment in this task after the hippocampal lesions. Selective lesions to CA1 of rats by ibotenic acid caused deficits in Morris maze task. The monkey team demonstrated functional dissociation after ischemia in monkeys. The human team also observed functional dissociation in memory tasks in hippocampal damaged patients. We organized an international symposium on "Comparative study of hippocampus" at Keio in 2004. Papers at this symposium will be published as a special issue of Reviews in Neurosciences journal.