Comparative psychological studies of spatial and temporal integration in hippocampus

本项目的目的是对海马功能进行比较研究，我们得到了如下结果。鱼类研究：我们对金鱼进行Morris-maze模拟实验，明确了背内侧端脑的病变选择性地损害空间学习而非地标学习。鸟类研究：我们使用鸽子、斑胸草雀和灌丛鸦。我们比较了射频、伊博tenic酸和抽吸对鸽子海马损伤的影响，发现每种方法都导致了严重的空间学习缺陷。另一方面，海马病变未引起WGTA样任务的严重缺陷。基底神经节病变延缓了wgta样任务的表现。斑马雀的病变研究与鸽子的一致，尽管这些雀是在大鸟舍里训练的。灌丛鸦通过观察其他鸟类的贮藏来获取空间信息，我们没有对灌丛鸦进行任何损伤研究。啮齿类动物研究：我们训练老鼠做一项任务，类似于鸽子重复的……更多获取过程。大鼠海马损伤导致了与鸽子实验相似的缺陷。我们研究了“空间认知”任务中的一些环境和行为变量，并比较了海马体损伤与finbria、颞叶皮层和杏仁核的影响。我们还研究了MNDA受体在空间认知中的作用。为了进行颞区区分，我们测量了颞区区分期间的海马θ波，并从内侧前额叶取样进行了微透析。缺血对C57小鼠Morris-maze也有影响，但对物体识别任务无影响。人类研究：我们开发了morris -s迷宫模拟手指迷宫，并比较了海马损伤前后在该任务中的表现。我们观察到右海马体损伤后出现发育迟缓，而右海马体损伤后没有。海马体受损的阿尔茨海默病和Korsakov患者的神经心理学检查显示空间和时间信息整合的缺陷。摘要：我们比较了几种不同物种的空间认知，发现从鱼类到人类，海马体在这些不同物种的空间认知中都起着作用。对于时空信息整合的比较研究，虽然我们获得了很多有趣的数据，但我们并没有完成研究。少

The purpose of the project is comparative study of hippocampal function and we obtained the results below.Fish study : We developed Morris-maze analog task for gold fish and clarified lesion in the dorsomedial telencephalon selectively damaged spatial learning but not landmark learning.Avian study : We used pigeon, zebra finches and scrub jays. We compared effect of hipocampal lesions by radiofrequency, ibotenic acid and aspiration in pigeons and found every method resulted in severe deficit in spatial learning. On the hand, the hippocampal lesions did not cause severe deficits in WGTA like task. The basal ganglion lesions retarded performance in the WGTA-like task. Lesions studies with the zebra finches agreed to those with pigeons even though the finches were trained in the large aviary. The scrub jays obtained spatial information by observing caching of the other birds, we did not done any lesion study with the jay.Rodent study: We trained rats on a task similar to pigeon's repeated … More acquisition procedure. The hippocampal lesions in rats resulted in a similar deficits to pigeon experiment. We examined several environmental and behavioral variables in "spatial cognition" tasks and compared effects of hippocampal lesions with those of finbria, temporal cortex and amygdale. We examined role of MNDA receptor in spatial cognition also. For temporal discrimination, we measured hippocampal theta- wave during temporal discrimination and also run microdialysis sampled from medial prefrontalis. Ischemia in C57 mice also caused deficits in Morris-maze but not in object recognition task.Human study : We developed Morris-s-maze analog finger-maze and compared performance in this task before and after the hippocampal lesions. We observed retardation after the right hippocampal lesions but not after the right hippocampal lesions. Neuropsychological examination of Alzheimer and Korsakov patients who had damages in the hippocampi showed deficits in integration of spatial and temporal information.Summary : We compared spatial cognition with several different species and found that the hippocampus has a role in spatial cognition through these different species from fish to human. For comparative study of integration of spatial and temporal information, we did not complete the research although we obtained a lot of interesting data. Less