Testing Effects of Environmental Exposures on Subsequent Human Generations

该项目旨在开发新的统计模型，以确定怀孕期间的环境暴露，如吸烟、饮酒和饮食，如何影响第一代和第二代儿童。该项目将填补在复杂性状遗传中分离遗传和环境因素的无偏见工具方面的空白，并将首次客观地确定环境暴露的影响是否以及如何可以遗传。通过国际合作和先进的跨学科方法，该项目将在新兴的多代遗传领域产生新的知识，以推动未来干预措施的设计，并影响怀孕期间的积极行为。

This project aims to develop new statistical models to determine how environmental exposures in pregnancy, such as smoking, alcohol consumption and diet, can impact the first and second generations of children. The project will fill a void in unbiased tools to disentangle genetic and environmental components in the inheritance of complex traits, and will be the first to determine objectively if and how effects from environmental exposures can be inherited. Through international collaborations and advanced interdisciplinary approaches, this project will generate new knowledge in the emerging field of multigenerational inheritance to drive the future design of interventions and influence positive behaviours during pregnancy.