Elucidate the meaning of chronobiological genotype for etiological mechanism of mood disorders

昼夜节律的紊乱，如睡眠-觉醒周期、体温，经常是情绪障碍的特征。研究人员已经发展出时间生物学理论来解释这种观察。社会节律疗法是从情绪障碍的时间生物学模型发展而来的，是专门为治疗情绪障碍而设计的一种有效的心理疗法。因此，情绪障碍被认为与昼夜节律紊乱有关，昼夜节律基因的多态性可能会影响情绪障碍。为了验证这一假设，在双相情感障碍患者和对照组中，对人类hper2基因的已报道区域进行了突变筛查，其中hper2突变加速了人类的昼夜节律。我们筛查了88例双相情感障碍患者和127例正常对照。但是我们没有发现基因和表型之间的任何关系，我们还试图通过Horne-Osberg早晚评分来了解Hper1对睡眠习惯性的影响。我们在hper1基因中发现了一个氨基酸替换的SNP。但在134名正常对照中，hper1新单体型与睡眠习惯性无关。为了找到心境障碍的时间生物学理论的分子机制，可能需要进一步研究时钟相关基因。

Disruptions in circadian rhythm such as the sleep-wake cycle, body temperature, frequently characterize mood disorder. Researchers have developed chronobiological theories to explain such observation. And social rhythm therapy, which grew from the chronobiological model of mood disorder, is an effective psychotherapy specially designed for the treatment. Therefore, mood disorder is thought to be associated with disturbed circadian rhythms, and there is a chance that polymorphism of the circadian gene might influence mood disorder.To test this hypothesis, mutation screening was performed in the reported area of the human hper2, in which are a mutation accelerates human circadian rhythm, in bipolar disorder patients and controls. We screened 88 patients with bipolar disorder and 127 normal controls. But we cannot find any relation between genotype and phenotype.We also try to realize the hper1 influences with sleep habituation by using the Horne-Osberg morningness-evening score. We find one SNP with amino acid substitution in hper1 gene. But there was no relation between hper1 new haprotype and sleep habituation of 134 normal controls.To find a molecular mechanism of chronobiological theory of mood disorder, further investigation of clock relevant gene may need.