Development of magnetic resonance techniques to evaluate diabetic cardiopathy

应用电子束CT(C-100，Imatron)对101例糖尿病患者和104例非糖尿病患者的冠状动脉内膜钙(CAC)进行了检测。与非糖尿病患者相比，糖尿病患者的平均CAC评分更高(281±474比183±335)，CAC评分大于401的比例更高(25%比15%)，被定义为冠心病的高危患者。为评价左冠状动脉主干(LM)和右冠状动脉(RCA)主干的异常循环，采用FastCard-Cine-PC磁共振成像技术，在单次屏气20s(Signa Horizon-LX，GE)条件下进行心电门控，获得血流速度波形和平均血流速度。CAC积分大于401分的糖尿病患者(n=7)与非糖尿病患者(n=5)相比，左、右冠状动脉血流速度明显降低(9.0±2.4比14.1±5.0 cm/s)和(9.3±2.7比12.9±4.8 cm/s)。这些发现表明，冠状动脉的扩张性增加了动脉的血流阻力，降低了血流速度。

Agatston coronary artery calcium (CAC), as a marker of intimal atheroma, was obtained in 101 diabetic patients and 104 non-diabetic subjects using electron beam computed tomography (C-100, Imatron). Diabetic patients had higher mean CAC score (281±474 vs. 183±335) and higher prevalence of CAC score more than 401 (25% vs. 15%), defined as high-risk patients for coronary artery disease, compared to those in non-diabetic subjects. To evaluate abnormal circulation in the main trunk of the left main coronary artery (LM) and right coronary artery (RCA), velocity waveform and mean flow velocity were obtained using Fastcard-cine-PC magnetic resonance imaging with ECG gating during single breath hold of 20 seconds (Signa Horizon-LX, GE). Diabetic patients with CAC score greater than 401 (n=7) showed abnormal velocity waveform and had lower flow velocities in LM (9.0±2.4 vs. 14.1±5.0 cm/sec) and in RCA (9.3±2.7 vs. 12.9±4.8 cm/sec) compared to those in the non-diabetic subjects (n=5). These findings suggest that distensibility of coronary artery increase arterial resistance to blood flow and reduce flow velocity.