The Withdrawal of Immunosuppressive Regimen by CD15s monitoring

在ABO血型不相容的肾移植中，我们经历了超急性排斥反应导致移植物丢失。在此期间，我们观察到CD15s抗原快速升高，有两个高峰。双色流式细胞术分析表明，该峰为CD10Ab染色的活化浆细胞。脾切除术不被认为能激活受体脾脏的记忆性B淋巴细胞。我们在动物实验中也得到了类似的结果。在停止免疫抑制后，观察到CD15s的高表达和senu肌酐的升高。

In ABO incompatible renal transplantation, we experienced hyper acute rejection leading to graft loss. During this period, we observed the rapid elevation of CD15s Antigen with two high peaks. Double color flow cytometric analysis demonstrated that this high peak was activated plasma cells stained by CD10Ab. No performance of splenectomy was believed to activate memory B lymphocytes in recipient's spleen. We obtained the similar result in animal experiments. High expression of CD15s was observed with senu creatinine elevation after withdrawal of Immunosuppression.