Comprehensive Basic Research for Development of Advanced, Innovative Permanent Artificial Heart Systems

本研究进行了以下几个方面的基础研究：1。在基于机电原理的脉动式人工心脏中，通过在摩擦表面涂覆类金刚石碳涂层，提高了螺杆机构的耐久性。心室辅助装置在37℃的温度下持续工作13个月。支持滚子丝杠运动的滚珠轴承故障导致研究终止。为实现机械无接触离心血泵，研究了磁悬浮机理。研制了一种二自由度磁悬浮系统，实现了一次性体外血泵和植入式系统。磁悬浮系统的功率需求降低到1.0瓦以下，可控性小于20微米。MagLev离心血泵的溶血性能比临床标准B - More PX-80.3提高了6-7倍。对第2部分设计的磁悬浮离心血泵的机械设计进行了计算流体动力学（CFD）分析。为了优化泵的设计，还进行了流动可视化来验证数值预测。基础研究也扩展到红细胞在循环逆转剪切流动下的变形和恢复响应。利用特制的剪切流发生器模拟离心血泵内部的情况。研究结果可用于改进血泵的设计。利用光纤技术研制了用于检测心血管装置内血栓形成的光学反射传感器。研究其在氧合器和血泵中的应用。开发了一种外科导航系统来辅助人工心脏系统的植入。术前利用该装置的CT图像和CAD数据为患者构建合适的植入方案。样机在小牛体内进行了VAD植入试验。少

In this research, basic research covering following items was conducted ;1.In the pulsatile artificial heart that is based on the electromechanical principle, the durability of the roller screw mechanism was improved by coating the friction surface with a diamond-like-carbon coating. The ventricular assist device continued to operate for duration of 13 months in the 37 degree C bath. The failure in the ball bearing that supports the roller screw movement caused termination of the study.2.Magnetic levitation (MagLev) mechanism was investigated to achieve a mechanical contact-free centrifugal blood pump. A two-degree-freedom MagLev system was developed to attain a disposable extracorporeal blood pump and an implantable system. The power requirement in the MagLev system was reduced to less than 1.0watt with controllability being less than 20 micron meter. The hemolytic performance of the MagLev centrifugal blood pump was improved by a factor of 6-7 in comparison to the clinical standard B … More PX-80.3.The computational fluid dynamics (CFD) analysis was conducted to evaluate the mechanical design of the MagLev centrifugal blood pump designed in section 2. Flow visualization was also carried out to verify the numerical predictions to optimize the pump design.4.Basic research was also extended to evaluate the deformation and recovery response of red blood cells under cyclically reversing shear flow. A specially built shear flow generator was used to simulate a condition similar to that inside the centrifugal blood pumps. The results of the study can be used to improve the blood pump design.5.The optical reflectance sensor utilizing the fiber-optics was developed to detect thrombus formation inside the cardiovascular devices. Its application in oxygenators and blood pumps will be investigated.6.A surgical navigation system was developed to assist implantation of the artificial heart system. The CT images and CAD data of the device were used to construct the proper implantation scheme of the device in patients prior to surgery. The prototype was tested in calf for VAD implantation. Less