Molecular genetic epidemiology based on the community cohort database in Chiang Rai, Thailand

泰国正在开发各种卫生信息数据库，如结核病监测数据库、艾滋病毒/艾滋病监测数据库或WINTHO(WINDOWS地区卫生数据库)数据库。WINTHO数据库已在初级保健机构：保健中心和初级保健单位(PCU)开发。WINTHO数据库包括个人名单、出生和死亡事件、访问卫生机构的日期和登记为初级保健的人口的诊断。在泰国最北部的清莱省，我们编制了WINTHO信息和结核病数据库，用于传染病的流行病学研究。结果：根据结核病监测数据库，1995-2003年登记病例数为12511人。2)总体来说，登记人数基本稳定。然而，在城市地区，这一下降趋势是明显的。死亡病例的趋势几乎是相同的。3)在一些地区，拖欠贷款的人数或比率急剧下降，从1995-1998年的平均30-65%下降到2001-2003年的10-15%。结果2：我们比较了WINTHO数据库和结核病监测数据库的结核病患病率。我们发现，WINTHO数据库中的结核病患者数量多于结核病监测数据库中的患者数量。尤其是WINTHO的肺外结核病数量较多。虽然这一趋势的原因目前正在调查中，但我们推测这种差异的一些因素，如寄存器泄漏、编码错误。结果3：RFLP调查正在分析中。到目前为止，已经检查了100多个样本。

In Thailand, various kinds of health information databases are being developed, e.g. tuberculosis surveillance database, HIV/AIDS surveillance database or WINTHO (District Health Database for WINDOWS) database. WINTHO database has been developed at primary health care facilities : health centers and primary care unit (PCU). The WINTHO databases include a list of individuals, events of birth and death, date of visit to health facility and diagnosis for population registered for primary care. In Chiang Rai province, one of the northernmost provinces of Thailand, we compiled WINTHO information and Tuberculosis database for epidemiologic research on infectious diseases.Results1 : Based on the tuberculosis surveillance database, the number of registered patients was 12,511 during 1995 to 2003. 2)As a whole, the number of registrants was almost stable. However, the decreasing trend was apparent among urban districts. The trend of death case is almost same. 3)In some districts, the number or the rate of defaulters was drastically decreasing from 30-65% in 1995-1998 average to 10-15% in 2001-2003. We also expressed this trend on GIS map.Results2 : We compared tuberculosis prevalence between WINTHO database and tuberculosis surveillance database. We found that the number of tuberculosis patients in WINTHO database is larger than tuberculosis surveillance database. Especially, the number of extrapulmonary tuberculosis is larger in WINTHO. Though the reason of this trend is now under survey, we speculate some factor of this difference such as register leakage, coding error.Results3 : RFLP survey is under analysis. So far, more than 100 specimen are examined.