Formation of polyamino acids in the prebiotic conditions : production mechanisms and structures.

阐明生命起源前多聚氨基酸的形成对生命起源的研究具有重要意义。只有一组有限的氨基酸已被报道，以recrystallized.In这项研究中，寡肽形成的水溶液中的精氨酸和脲氨基酸混合物的加热实验中，其特征在于单独使用液相色谱-质谱仪。精氨酸和其他氨基酸的共聚反应被很好地表征为我们先前论文中提出的酰胺交换机制。我们还证明了一种新的热聚合在熔融脲的烷基氨基酸（即甘氨酸，丙氨酸，α-丙氨酸，β-氨基丁酸，缬氨酸，正缬氨酸，亮氨酸，正亮氨酸），已被认为是不能进行热聚合。此外，天冬氨酸被发现在熔融尿素中在比天冬氨酸单独先前已热聚合的温度更低的温度下发生聚合。利用熔融尿素的高极性和脱水能力进行聚合反应。在假定的益生元条件下，多种氨基酸发生了热聚合反应，获得了益生元条件下多聚氨基酸形成的新信息。此外，我们还发现了未来生命起源研究的方向性。

It is important for research of the origins of life to elucidate polyamino acid formation in the prebiotic conditions. Only a limited set of amino acids has been reported to polymerize thermally.In this study, oligopeptides formed in the heating experiments of aqueous aspargine and ureaamino acids mixtures were characterized individually using a liquid chromatograph-mass spectrometer. Cooligomerization of aspargine and other amino acids were well characterized as the amide exchange mechanism proposed in our previous paper. We also demonstrate a novel thermal polymerization in molten urea of alkylamino acids (i.e.glycine, alanine, α-alanine, β-aminobutyric acid, valine, norvaline, leucine, and norleucine) which had been thought to be incapable of undergoing thermal polymerization. Also, aspartic acid was found to polymerize in molten urea at a lower temperature than that at which aspartic acid alone had previously been thermally polymerized. The polymerization reaction occurred by taking advantage of molten urea's high polarity as well as its dehydrating ability. Under the presumed prebiotic conditions employed here, many types of amino acids were thus revealed to undergo thermal polymerization.Some novel information of polyamino acid formation in the prebiotic conditions were obtained through this study. In addition, we found some directivity in future research for the study of origins of life.