Study on the Molecular Assembly Using Cholic Acid

1)三脚架胆酸衍生物的分子识别：研究了由三个胆酸分子与均苯三甲酸和环三苯异丙乙烯制备的三脚架对脱氧核糖核苷和AZT的识别。<-1>在固液萃取中使用胆酸甲酯系链获得了dA的最大结合常数（5 × 10^5 M^）。观察到AZT的弱结合（10^2 M^<-1>）。2）双环胆甾烷的X-射线结构测定：含有甾体部分的大环化合物的X-射线结构几乎没有报道。我们成功地测定了双环胆甾烷的X-射线结构，其晶体结构具有P-螺旋性，胆酸柱是扭曲的。3）胆酸衍生物液晶的制备实验：为了制备胆酸衍生物的二聚型液晶分子，制备了各种具有长芳基和长烷基链的胆酸盐。不同于胆固醇是一种扁平的类固醇，我们期望从L形弯曲型类固醇中获得独特的液晶性质。4）用于分子识别的液晶分子的制备：由高氧杂[4]芳烃衍生物制备了自组装液晶相，其核心部分可能作为潜在的分子识别位点。

1)Molecular recognition by tripodant cholic acid derivatives : Tripodants prepared from three molecules of cholic acids with trimesic and cyclotriverahylene were investigated for recognition of deoxyribonucleosides and AZT The largest binding constant (5 x 10^5 M^<-1>) was obtained for dA using a methyl cholate tether in solid -liquid extraction. Weak binding (10^2 M^<-1>) was observed for AZT.2)X-ray structural determination of a bicyclocholaphane : X-ray structure of macrocycles containing steroidal moiety has hardly been reported. We succeeded to determined the X-ray structure of bicyclocholaphane which possessed P-helicity in its crystal structure, the cholic acid pillars were twisted., while it had two twisted diastereomeric forms in solution.3)Trial to prepare liquid crystalline cholic acid derivatives : In order to prepare dimeric type of liquid crystalline molecules of cholic acid derivatives, various kinds of cholate possessing long aryl and alkyl chains were prepared. Unlike cholesterol which is a flat steroid, we expected to have unique liquid crystalline properties from the L-shaped bent type steroids. However, they did not show liquid crystal phases yet.4)Preparation of a liquid crystalline molecule for molecular recognition: Self-assembled liquid crystal phases were prepared from homooxacalic[4]arene derivatives Its core part may behave as a potential molecular recognition site.