New Horizons in Diels-Alder Chemistry

使用独特的联合实验-计算方法，我们将开发可靠的方法来预测最重要的化学反应之一的结果。这些新的预测工具的实际应用将涉及强大的新版本的反应。将制备几种不同类别的生物活性天然产物，包括具有抗肿瘤和抗逆转录病毒活性的分子。将合成天然化合物的结构相关类似物库，用于生物学评价。

Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-related analogues of natural compounds will be synthesised for biological evaluation.