The association with bFGF, HGF and protection of neural system and cardio-vascular disease.

本研究的目的是探讨bFGF在（碱性成纤维细胞生长因子）和HGF本研究旨在探讨肝细胞生长因子（Hepatocyte growth factor，HGF）与社区人群中风和急性心肌梗死的关系，并检验这些因素是否能独立于普通心血管危险因素而预测心血管疾病的风险（1 541名男子和2 934名妇女）。1996年4月至1998年12月进行了一次基线调查。基线调查后至2004年12月31日前发生的心血管事件纳入分析。本队列研究采用巢式病例对照研究，病例与对照按1：3抽样。在统计分析中，使用多元回归分析校正吸烟习惯和其他顺序心血管危险因素后计算相对危险度。经过30，885人年的随访，记录了96例卒中病例和12例急性心肌梗死病例。bFGF和HGF与脑卒中和心血管疾病的风险呈负相关。校正其他危险因素后，bFGF与HGF呈显著负相关，提示bFGF和HGF是此类疾病的独立危险因素。我们发现这些因子对体内组织缺血具有保护作用。

The aim of this study was to investigate bFGF (basic Fibroblast Growth Factor) and HGF (Hepatocyte growth factor) with relation to risk of stroke and acute myocardial infarction in the community population and to examine whether such factors were useful for the prediction for cardio-vascular disease risk, independent of ordinary cardio-vascular risk factors.At first, we constructed a population-based cohort study of 4,475 subjects (1,541men and 2,934 women). A base-line survey was conducted between April 1996 and December 1998. Cardio-vascular events were included in the analysis if the occurred after date of base-line survey and before December 31, 2004.In this cohort study, we calculated nested case-control study and sampled cases and controls by 1:3. At statistical analyses, the relative risk was calculated after adjusting for smoking habits and other ordinal cardio-vascular risk factors using the multiple regression analysis.After 30,885 person-year follow-up, 96 stroke cases and 12 acute myocardial infarction cases were documented. The bFGF and HGF was negatively associated with risk of stroke and cardio-vascular diseases. And HGF was negatively associated significantly after adjusted other risk factors.In conclusion, our study indicated that bFGF and HGF were independent risk factors for such diseases. And we found these factors had a potential of protection for tissue-ischemia in vivo.