Development of bone quality evaluation mapping sheet

本课题的目的是建立一种基于数学形态学的形态滤波器的骨结构分析方法，并进行组织病理学骨形态计量学的研究，同时尝试开发颌骨骨质量评价的映射表。本研究计划开发一个骨质量评价系统，本研究采用以下方法开发了骨质量评价系统：1）利用基于形态滤波器的骨架运算，从二维图像中提取骨小梁结构的骨架模式。用骨形态计量学指标（Sk.Ar、Sk.Pm、Sk.Th、Sk.N、Sk.Sp、FD、MIL、TBPf、N.Nd、N.CtNd等）对这些模式进行定量评价。2）为获得理想的二维图像标准，采用三维骨结构分析。3）制作骨质量评价绘图表，记录骨骼结构、骨强度（截面二次矩）和骨密度指数（BMD）; 4）应用该系统对食蟹猴骨质疏松模型进行骨质量评价。5）完成了基于临床典型诊断图像的颌骨疾病诊断和治疗效果检测的骨结构评价系统，该系统已获得专利（No.3799603）。

The purposes of this project were to establish the method for bone structural analysis, using morphological filter based on mathematical morphology, histo-pathological bone morphometry and an attempt the development of the mapping sheet for evaluating bone-quality of the jaw bone. We planed to develop a bone quality evaluation system.We developed the bone quality evaluation system by using the following ;1)We detected bone trabecular structure as skeletal patterns derived from two-dimensional images using skeleton operation based on morphological filter. These patterns were evaluated quantitatively by using bone morphometric indices (Sk.Ar,Sk.Pm,Sk.Th,Sk.N,Sk.Sp,FD,MIL,TBPf,N.Nd,N.CtNd, etc.).2)To obtain ideal standard for the two-dimensional images, we used three-dimensional bone structure analysis. According to the results, we determined optimal parameters for this analysis.3)We made the bone quality evaluation mapping sheet, for recording skeleton structure, bone strength (sectional quadratic moment) and bone mineral density index (BMD).4)We applied this system using digital dental radiography to evaluation bone quality on the osteoporotic model of the cynomolgus monkeys. And clinical images evaluated are ; cyst, tumor, and dental implant, etc.5)Bone structure evaluation system for diagnosis and detecting therapy effect of the jaw disease, based on clinical typical diagnostic images was completed.This system has acquired a patent(No.3799603).