Bone morphometric imeging using morphological filter.

使用形态滤波器进行骨形态测量成像。

• 批准号: 09470416
• 负责人: KASHIMA Isamu
• 金额: $ 8.58万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470416/
• 关键词: Mthematical morphology; Computed Radiography; Bone mineral density; Star volume analysis; Bone quality; Bone structure; Morphological filter; モルフオジカルフィルター; コンピュータ診断支援システム; X線診断学; 形態画像診断; コンピューテットラジオグラフィー; モルフォジカルフィルター

Structuring parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra to evaluate the therapeutic efficiency of medication on osteoporosis.The trabecular bone pattern of each bone block was binarized into a trabecular skeletal pattern and they were quantified into a trabecular skeletal pixel percentage (SKP) and trabecular skeletal star volume (Vt) by star volume analysis. Then the bone mineral density (BMD) and elasticity of each bone block were measured by dual x-ray absorptiometry and mechanical tests to determine the correlations between SKP and Vt.In the present study, no significant correlations were observed between BMD and elasticity. Elasticity differed greatly between some bone blocks even though BMD was essentially the same. Grid-like skeletal patterns consisting of vertical and horizontal continuous lines showed higher elasticity. SKP showed higher correlations with elasticity than BMD, although the fluctuation range was narrow. Meanwhile, Vt showed higher correlations with elasticity than SKP, and the SKP-BMD and Vt-BMD correlations were weak.These results indicate that SKP and Vt obtained by star volume analysis using a morphological filter are more effective than BMD as structural parameters for analyzing the therapeutic efficiency of medication on lumbar vertebra.

为评价药物治疗骨质疏松症的疗效，采用18块第三腰椎松质骨块，将骨块的松质骨模式二值化为骨小梁模式，并通过星星体积分析将其量化为骨小梁像素百分比（SKP）和骨小梁星星体积（Vt）。然后通过双能X线吸收法和力学测试测量每个骨块的骨密度（BMD）和弹性，以确定SKP和Vt之间的相关性。在本研究中，BMD和弹性之间没有观察到显著相关性。尽管BMD基本相同，但某些骨块之间的弹性差异很大。由垂直和水平连续线条组成的网格状骨架图案显示出更高的弹性。SKP与弹性的相关性高于BMD，但波动范围较窄。同时，Vt与弹性的相关性高于SKP，而SKP-BMD和Vt-BMD的相关性较弱，表明用形态滤波器进行星星体积分析得到的SKP和Vt作为腰椎药物疗效分析的结构参数比BMD更有效。

项目成果

Satsuki KUMASAKA 以下3名: "Comparison of Extracted patterns of femur and jumeru using the line skeleton operation process and skeleton operation process."Oral Radiology. Vol.5・No2. 105-110 (1999)

Satsuki KUMASAKA：“使用线骨骼操作过程和骨骼操作过程提取股骨和股骨的模式的比较”口腔放射学第 5 卷·第 105-110 期（1999 年）。

Koji NAKAMURA 以下5名: "Mathematical Morphology for Extraction of Bone Trabecularal Pattern Premilinary lnvestigation of Quantitative Analysis Using the Star Volume"J Jpn Soc Bone Morphom. 9巻. 45-51 (1999)

Koji NAKAMURA 以下 5 人：“利用星卷定量分析的骨小梁模式提取的数学形态学初步研究”Jpn Soc Bone Morphom 卷 9. 45-51 (1999)。

鹿島 勇: "骨構造解析" INNERVISION. 13巻11号. 39-44 (1998)

鹿岛勇：《骨结构分析》INNERVISION，第 13 卷，第 11 期，39-44（1998 年）

Koji NAKAMURA, Masaaki MATSUBARA, Hideomi FUJIKAWA, Atsushi KOYAMA, Takayoshi FUJIKAWA, Isamu KASHIMA: "Mathematical Norphology for Extraction of Bone Trabecularal Pattern Premilinary Investigation of Quantitative Analysis Using the Star Volume."J Jpn Soc

Koji NAKAMURA、Masaaki MATSUBARA、Hideomi FUJIKAWA、Atsushi KOYAMA、Takayoshi FUJIKAWA、Isamu KASHIMA：“使用星体进行定量分析的骨小梁模式提取的数学形态学初步研究。”J Jpn Soc

Satsuki KUMASAKA, Shiro KIYOHARA, Tsuneo TAKAHASHI, Hideomi ASAI, Isamu KASHIMA: "Morphologically extracted trabecular skeleton superimposed upon digital radiograph structure."J. of Bone Mineral Metabolism. Vol.18, No.4. (2000)

Satsuki KUMASAKA、Shiro KIYOHARA、Tsuneo TAKAHASHI、Hideomi ASAI、Isamu KASHIMA：“形态学提取的小梁骨架叠加在数字射线照片结构上。”J.