Bone morphometric imeging using morphological filter.

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Structuring parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra to evaluate the therapeutic efficiency of medication on osteoporosis.The trabecular bone pattern of each bone block was binarized into a trabecular skeletal pattern and they were quantified into a trabecular skeletal pixel percentage (SKP) and trabecular skeletal star volume (Vt) by star volume analysis. Then the bone mineral density (BMD) and elasticity of each bone block were measured by dual x-ray absorptiometry and mechanical tests to determine the correlations between SKP and Vt.In the present study, no significant correlations were observed between BMD and elasticity. Elasticity differed greatly between some bone blocks even though BMD was essentially the same. Grid-like skeletal patterns consisting of vertical and horizontal continuous lines showed higher elasticity. SKP showed higher correlations with elasticity than BMD, although the fluctuation range was narrow. Meanwhile, Vt showed higher correlations with elasticity than SKP, and the SKP-BMD and Vt-BMD correlations were weak.These results indicate that SKP and Vt obtained by star volume analysis using a morphological filter are more effective than BMD as structural parameters for analyzing the therapeutic efficiency of medication on lumbar vertebra.